Totally Natural LifeEZE Plus With SAMe Tab X 60

One of Europe's biggest selling natural supplement for lifting mood, relieving stress, nervous tension and mild anxiety is now available in Australia!

LifeEZE Plus contains SAMe, which has a calming effect on the mind, enabling you to think more clearly and keeping you in a positive frame of mind.


WHAT IS SAMe?

S-adenosylmethionine (SAMe) is a physiological molecule occurring naturally in the tissues of the body, predominately in the liver, adrenal and pineal glands.

An important metabolic intermediate, SAMe is synthesised in vivo from ATP (adenosine triphosphate) and L-methionine by SAMe synthetase to form a molecule composed of a purine (adenine: 6-aminopurine), a sugar (deoxyribose) and an amino acid (L-methionine).

HISTORY OF SAMe

SAMe was first brought to attention by an Italian, Cantoni in 1951. It was an unstable molecule and could not be studied in clinical trials until it became commercially available in 1974. An Italian group devised a way of stabilizing S-adenosylmethionine by producing a derivative stabilized with p-toluene sulfate.

Since then numerous studies have been carried out showing that SAMe participates in a variety of biological reactions. SAMe has been used clinically in Europe since the 1970's and is today the most prescribed natural supplement for stress, nervous tension, anxiety and low mood in Europe.

'In the USA SAMe became available in 1999 as a dietary supplement and is now the most purchased over-the-counter supplement in the United States!'

Clinical studies using exogenous (oral or parenteral) SAMe have found beneficial effects for those suffering from stress, nervous tension, anxiety, low mood, osteoarthritis, poor liver function as well as a number of other health conditions.

1. LIFTING ANXIETY, STRESS& LOW MOOD

SAMe has experimentally shown to be effective with those suffering from low mood disorders. SAMe stimulates the activity of dopaminergic and serotonergic pathways in the brain through its involvement in the transmethylation processes. Levels of SAMe synthetase and phosphatidylcholine have been shown to be reduced in the erythrocytes of patients with low mood suggesting a disruption in SAMe pathways. This has formed the basis for the use of SAMe for the relief of stress and associated conditions, particular those suffering with a low mood.

Clinical trials conducted have shown SAMe to be as effective, in the low to moderate dosages, as drugs. The beneficial effects of SAMe began more quickly and produced fewer side effects.

The effect of SAMe in patients suffering from anxiety and associated health problems is seen by a consistent improvement in mood as determined by the Hamilton rating scale.

Patients were given daily dosages of up to 1600mg daily with an onset of action within the first two weeks of treatment and no adverse effects noted.

2. OSTEOARTHRITIS

SAMe plays an important role in cartilage formation and repair. To date, a total of 22,261 patients have participated in clinical trials in the treatment for pain of osteoarthritis. 21,524 were given SAMe, 458 were given different NSAIDs and 279 given placebo. The trials were conducted over a period of three weeks to two years and dosages ranged from 400 - 1200mg daily. Data from the controlled trials have shown SAMe's superiority to placebo and a similar degree of efficacy as NSAIDs without side effects when compared long term. Unlike NSAIDs' the current choice of treatment for the relief of pain for osteoarthritis, SAMe does not inhibit prostaglandin synthesis, does not cause gastrointestinal damage and does not inhibit platelet aggregation. Instead, SAMe promotes in vitro synthesis of proteoglycans by human chondrocytes, is free from systemic side effects and exhibits clinical effectiveness.

3. HELPS LIVER FUNCTION

SAMe has shown hepatoprotective effects in clinical trials. In patients presenting with liver problems such as metabolism of methionine, transmethylation and transsulphuration pathways are impaired reducing the activity of SAMe synthetase, the enzyme required for synthesizing SAMe from ATP and L-methionine. S-adenosylmethionine is able to increase the intracellular glutathionine (the main cellular anti-oxidant) levels in the liver by activating the transsulphuration pathway, which is known to be low in those who may have sluggish liver rendering it effective in this area.

Directions for taking LifeEze Plus:
Take 1 tablet daily for the first 4 days and then increase to 2 tablets daily if needed, or as directed by a health care professional.
1 DAILY - Take in the morning with breakfast.
2 DAILY - Take one tablet morning with breakfast and again with evening meal.


CAUTION
VERY IMPORTANT - PLEASE READ!

The information in this brochure is provided for health educational purposes and is not intended as medical advice. Individuals who are using prescription anti-depressants or suffer from bipolar depression should not use this product unless under the supervision of a health care professional. If symptoms persist, please seek help from your health care professional.